Inhaled interleukin-10 before and after induction of experimental endotoxemia in the rat [Elektronische Ressource] : effects on the inflammatory response / vorgelegt von Nguyen, Ngoc Thach

Aus dem Fachbereich Medizin der Johann Wolfgang Goethe-Universität Frankfurt am Main Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie Direktor Prof. Dr.med. Dr.med.habil. Bernhard Zwissler Inhaled Interleukin-10 before and after induction of experimental endotoxemia in the rat. Effects on the inflammatory response. Dissertation zur Erlangung des Doktorgrades der Medizin des Fachbereichs Medizin der Johann Wolfgang Goethe-Universität Frankfurt am Main vorgelegt von Nguyen, Ngoc Thach aus Hanoi, Vietnam Frankfurt am Main, 2007 Dekan : Prof. Dr. J. Pfeilschifter Referent : Prof. Dr. B. Zwißler Koreferent: Priv. - Doz. Dr. H. Mühl Tag der mündlichen Prüfung: 21. August 2007 To my wife Hà Thị Thu Hiền and daughter Nguyễn Hà Quỳnh Anh and to the memories of my father Prof. Nguyễn Hữu Mô and my mother Thạch Thị Lợi. CONTENT Pages Abbreviations 1. Introduction 1 1.1. Definition and Epidemiology of Acute Respiratory Distress Syndrome (ARDS) 1 1.2. Etiology and Pathophysiology of ARDS 1 1.2.1. Etiology of ARDS 1 1.2.2. Pathophysiology of ARDS 2 1.3. Anti-inflammatory Therapy and ARDS 3 1.3.1. Interleukin-10 and ARDS 3 1.4. Objective 5 2. Materials and Methods 6 2.1. Animals 6 2.2. Anaesthesia and Surgical Preparation 6 2.3. Mechanical Ventilation 8 2.4. Nebulisation 8 2.5. Experimental Protocol of the Present Study 11 2.5.1. Preparation of LPS 11 2.5.2.