Influence of E-LDL and Ox-LDL on the metabolism of ApoE, cholesterol, sphingolipids and glycosphingolipids as well as on the raft-composition in human macrophages [Elektronische Ressource] / vorgelegt von Margot Grandl

Influence of E-LDL and Ox-LDL on the Metabolism of ApoE, Cholesterol, Sphingolipids and Glycosphingolipids as well as on the Raft-Composition in Human Macrophages DISSERTATION ZUR ERLANGUNG DES DOKTORGRADES DER NATURWISSENSCHAFTEN (DR. RER. NAT.) DER FAKULTÄT FÜR CHEMIE UND PHARMAZIE DER UNIVERSITÄT REGENSBURG vorgelegt von Margot Grandl aus Regensburg 2005 Promotionsgesuch eingereicht am: 22.12.2005 Die Arbeit wurde angeleitet von: Prof. Dr. Gerd Schmitz Prüfungsausschuß: Vorsitz: Prof. Dr. Sigurd Elz 1. Gutachter: Prof. Dr. Armin Buschauer 2. Gutachter: Prof. Dr. Gerd Schmitz 3. Prüfer: Prof. Dr. Jörg Heilmann This work was performed at the institute of Clinical Chemistry and Laboratory Medicine at the University of Regensburg between September 2001 and December 2005 under the supervision of Prof. Dr. Gerd Schmitz. Table of contents Table of contents I. Introduction Page 1. Pathogenesis of atherosclerosis 1 1.1. Response to injury hypothesis 2 1.2. Response to retention hypothesis 3 2. Cellular constituents of atherosclerosis 3 2.1. Differential expression of the monocyte innate immunity receptor complex defining monocyte subpopulations 4 2.2. Foam cell formation 6 3. Cholesterol transport 6 3.1.