Indoloquinoline-Oligonucleotide Conjugates in the antigene strategy [Elektronische Ressource] : binding and NMR structural studies. / Andrea Eick

Indoloquinoline-Oligonucleotide Conjugates in the Antigene Strategy: Binding and NMR Structural Studies I n a u g u r a l d i s s e r t a t i o n zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) an der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald vorgelegt von Andrea Eick geboren am 02.01.1982 in Königs Wusterhausen Greifswald, September 2011 Dekan: Prof. Dr. Klaus Fesser 1. Gutachter: Prof. Dr. Klaus Weisz 2. Gutachter: Prof. Dr. Gerd Buntkowsky Tag der Promotion: 28. November 2011 ± Table of Contents 1 Introduction .................................................................................................................................................... 1 2 General Concepts ........................................................................................................................................ 11 2.1 Physicochemical Methods in Nucleic Acids Research ....... 11 2.1.1 UV-Vis Spectroscopy ................................................. 11 2.1.2 CD Spectroscopy ....................................................................................... 12 2.1.3 Fluorescence Spectroscopy ....................................... 14 2-Aminopurine - Fluorescent Probe in Nucleic Acids Research .............