In vivo function of NGF-TrkA signaling in the cholinergic neurons of the murine basal forebrain [Elektronische Ressource] / vorgelegt von Markus Müller

In vivo function of NGF/TrkA signaling in thecholinergic neurons of the murine basal forebrainDissertationder Fakultät für Biologie der Ludwig-Maximilians-UniversitätMünchenVorgelegt vonMarkus MüllerMünchen 2005Dissertation wurde eingereicht am: 10.05.2005Tag der mündlichen Prüfung: 25.10.2005Prüfungskommission:Herr PD Dr. Rüdigher Klein (Vorsitz)Herr Prof. Dr. Stefan JentschHerr Prof. Dr. Benedikt GrotheHerr Prof. Dr. Hans-Ulrich KoopUmlauf:Herr PD Dr. Mark HübenerHerr Prof. Dr. George BoyanI TA B LE OF C O N TE N TSI TABLE OF CONTENTS _________________________________________________________ 2II ABBREVIATIONS ______________________________________________________________ 5III INTRODUCTION_____________________________________________________________ 81 NEUROTROPHIN SIGNALING___________________________________________________ 81.1 NEUROTROPHINS CONTROL CELL SURVIVAL _______________________________________ 101.2 NEUROTROPHINS CONTROL NEURONAL DEVELOPMENT AND FUNCTION __________________ 132 NGF AND ITS RECEPTOR TRKA ________________________________________________ 152.1 EXPRESSION PATTERN OF NGF AND TRKA ________________________________________ 162.1.1 Expression in the PNS __________________________________________________ 162.1.2 Expression in the CNS __________________________________________________ 162.1.3 Expression in non-neuronal cells __________________________________________ 172.