In vitro and in vivo characterization of alginate based anisotropic capillary hydrogels to guide directed axon regeneration [Elektronische Ressource] / presented by Kiran Chandrakantrao Pawar

From the Institute of Physical and Theoretical Chemistry of the University of Regensburg IN VITRO AND N V V O CHARACTERIZATION OF A L G N A T EBASED ANISOTROPIC CAPILLARY HYDROGELS TO G U I D E DIRECTED AXON REGENER A T O N Doctoral Thesis To obtain the Academic Degree ‘Doctor rerum naturalium’ (Dr. rer. nat.) From the Faculty of Chemistry and Pharmacy University of Regensburg Presented by Kiran Chandrakantrao Pawar Born 15 June 1980 in Loha-Nanded, India Regensburg, August 2010 I I I IThis work was conducted in the Institute of Physical and Theoretical Chemistry and Department of Neurology in the University of Regensburg from April 2007 to August 2010 under supervision of Dr. Rainer Mueller and Prof. Dr. Norbert Weidner. Official registration: 15/06/2010 Defence: 20/09/2010 Ph.D. supervisor: PD Dr. Rainer Mueller Adjudicators: Prof. Dr. Norbert Weidner Prof. Dr. Armin Goepferich Chair: Prof. Dr. Werner Kunz Dedicated to my family Contents 1 Introduction and goal of thesis................................................................................ 1 1.1 Principles of regenerative medicine................................................................... 3 1.2 Biomaterials for regenerative medicine............................................................