In silico drug discovery on computational grids for finding novel drugs on neglected diseases [Elektronische Ressource] / Vinod Kumar Kasam

In silico drug discovery on computational Grids for finding novel drugs against neglected diseases Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultat der Rheinischen Friedrich-Wilhelms-Universitat Bonn vorgelegt von Vinod Kumar Kasam Aus Warangal, Indien Bonn September 2009 Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn. 1. Referent: Univ.-Prof. Dr. Martin Hofmann-Apitius 2. Referent: Univ.-Prof. Dr. Christa Mueller Tag der Promotion: 30.04.2010 Diese Dissertation ist auf dem Hochschulschriftenserver der ULB Bonn unter http://hss.ulb.uni-bonn.de verfügbar. Erscheinungsjahr: 2010 For my Family: My Wife and Son Abstract Abstract Malaria is a dreadful disease affecting 300 million people and killing 1-1.5 million people every year. Malaria is caused by a protozoan parasite, belonging to the genus Plasmodium. There are several species of Plasmodium infecting cattle, birds, and humans. The four species P.falciparum, P.vivax, P.malariae and P.ovale are in particular considered important, as these species infect humans.