Impact of Mdm2-p53 on the proteasome assembly and disassembly Role of the ubiquitination of some 19S subunits [Elektronische Ressource] / Justine Letienne. Betreuer: Christine Blattner

"Impact of Mdm2-p53 on the proteasome assembly and disassemblyRole of the ubiquitination of some 19S subunits"Zur Erlangung des akademischen Gradeseines Doktors der Naturwissenschaften von der Fakultät für Chemie und Biowissenschaften desKarlsruher Instituts für Technologie (KIT)genehmigte DissertationvonJustine Letienneaus Lescar, FranceHauptreferent: PD Dr. Christine BlattnerKorreferent: Prof. Dr. Jörg KämperTag der mündlichen Prüfung: 18.10.2011TABLE OF CONTENTSZUSAMMENFASSUNG .................................................................................... 5 ABSTRACT .........................................................................................................7 LIST OF FIGURES AND TABLES.................................................................. 8 ABBREVIATIONS ............................................................................................. 91. INTRODUCTION.........................................................................................111.1 The Ubiquitin Proteasome System “UPS”.................................................... 12 1.1.1 The ubiquitin conjugation pathway................................................................................. 12 1.1.1.1 Ubiquitination of substrates........................................................................................................12 1.1.1.2 E3 ubiquitin ligases .....................................................................................