Impact of folate absorption and transport for nutrition and drug targeting [Elektronische Ressource] / N. Ceren Alemdaroglu

Impact of Folate Absorption and Transport for Nutrition and Drug Targeting Dissertation zur Erlangung des Grades “Doktor der Naturwissenchaften” am Fachbereich Chemie, Pharmazie und Geowissenschaften der Johannes Gutenberg-Universität Mainz N. Ceren Alemdaroglu geb. in Ankara Mainz 2007 ii Dedicated to my husband, Fikri… v viTABLE OF CONTENTS Acknowledgements………………………………………………………………......vii Table of contents……………………………………………………………………..ix List of abbreviations…………………………………………………………………xi Chapter 1…...Chemistry, biochemical role, absorption and significance of folic acid & general aspects of flavonoids…….…………………...1 Objectives……………………………………………………………35 References……………………………………………………………37 Chapter 2…..In vitro cell culture studies, drug- and nutrient- interactions of folic acid ………………………....................................................51 Chapter 2.1…In vitro cell culture model for studying folic acid interactions……...53 Chapter 2.2…Expression of folate transport routes in Caco-2 cells: Reverse transcription PCR (RT-PCR) and real-time PCR……………………79 Chapter 2.3…Effect of green tea catechins and tea extracts on folic acid uptake….90 Chapter 2.