Impact of CYP3A5 genetic polymorphism on the biotransformation of drugs and environmental toxins [Elektronische Ressource] / von Landry Kamdem Kamdem

Impact of CYP3A5 Genetic Polymorphism on the Biotransformation of Drugs and Environmental Toxins Von der Fakultät für Lebenswissenschaften der Technischen Universität Carolo-Wilhelmina zu Braunschweig zur Erlangung des Grades eines Doktors der Naturwissenschaften (Dr. rer. nat.) genehmigte Dissertation von Landry Kamdem Kamdem Aus Nancy, France Prof. Dr. med. Dr. rer. nat. habil. Mathias 1. Referent: Schwanstecher Prof. Dr. med. Jürgen Brockmöller 2. Referent: 06.03.06 eingereicht am: 10.05.06 mündliche Prüfung (Disputation) am: (2006) The following parts of the thesis have been published after approval of the Faculty of Pharmacy and Chemistry, represented by the supervisor: Scientific publications: Kamdem LK, Meineke I, Koch I, Zanger UM, Brockmöller J and Wojnowski L. Limited contribution of CYP3A5 to the hepatic 6ß-hydroxylation of testosterone. Naunyn Schmiedebergs Arch. Pharmacol. 2004 Jul; 370(1):71-7. Epub 2004 Jul 01. Kamdem LK, Streit F, Zanger UM, Brockmöller J, Oellerich M, Armstrong VW and Wojnowski L. Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus. Clinical Chemistry. 2005 Aug.; 51 (8):1374-81. Epub 2005 Jun. 10. Schirmer M, Toliat MR, Haberl M, Suk A, Kamdem LK, Klein K, Brockmöller J, Nürnberg P, Zanger UM and Wojnowski L.