Identification of the novel Akt2 interacting proteins RPS25 and eIF3c [Elektronische Ressource] : characterization of interaction and physiological consequences / von Xuehui He

Identification of the novel Akt2 interacting proteins RPS25 and eIF3c: characterization of interaction and physiological consequences der Fakultät für Biologie der EBERHARD KARLS UNIVERSITÄT TÜBINGEN zur Erlangung des Grades eines Doktors der Naturwissenschaften von Xuehui He aus Henan/China vorgelegte D i s s e r t a t i o n 2007 Tag der mündlichen Prüfung: 25 June 2007 Dekan: Prof. Dr. Friedrich Schöffl 1. Berichterstatter: PD Dr. Reiner Lammers 2. Berichterstatter: Prof. Dr. Hans-Georg Rammensee Contents - 1 -Contents Contents.............................................................................................................................. - 1 - 1 Introduction .................................................................................................................... - 6 - 1.1 The structure of Akt...................................................................................................... - 6 - 1.2 The regulation of Akt.................................................................................................... - 8 - 1.2.1 PI3K dependent activation of Akt ........................................................................ - 8 - 1.2.2 Akt activation in lymphocytes............................................................................ - 10 - 1.2.3 Negative feedback control of Akt.............