Identification of microRNAs miR-203 and miR-335 forming a network of regulation in breast cancer development [Elektronische Ressource] / Holger Heyn

Identification of microRNAs miR-203 and miR-335 forming a network of regulation in breast cancer development Von der naturwissenschaftlichen Fakultät der Gottfried Wilhelm Leibniz Universität Hannover zur Erlangung des Grades DOKTOR DER NATURWISSENSCHAFTEN Dr. rer. nat. genehmigte Dissertation von Diplom-Biologe Holger Heyn Geboren am 29.01.1979, in Bremen 2010 1 Referentin: Prof. Dr. Schlegelberger Korreferentin: Prof. Dr. Gerardy-Schahn Tag der Promotion:18.12.2009 Schlagworte: MikroRNA, BRCA1, Brustkrebs Keywords: MicroRNA, BRCA1, Breast cancer2 Content Content 1 Summary ...................................................................................................................... 1 1.1 Zusammenfassung ................................... 2 2 Introduction ................................................................................................................. 3 2.1 BRCA1 and breast cancer formation ....... 3 2.2 The inhibitor of DNA binding (ID4) ....................................................................... 5 2.3 The estrogen receptor α (ERα) ................ 6 2.4 The aryl hydrocarbon receptor (AhR) ..................................................................... 7 2.5 The insulin-like growth factor 1 receptor (IGF1R) ................. 8 2.6 The specificity protein 1 (SP1) ....................................................................