Identification of large-scale DNA copy number differences between human and non-human primate genomes and their role in mediating evolutionary rearrangements [Elektronische Ressource] / presented by Violaine Goidts

University of Ulm Department of Human Genetics Prof. Dr. Walther Vogel Identification of Large-Scale DNA Copy Number Differences Between Human and Non-Human Primate Genomes and their Role in Mediating Evolutionary Rearrangements Dissertation To obtain the doctoral degree of Human Biology At the Faculty of Medicine, University of Ulm Presented by Violaine GOIDTS from Namur, Belgium Ulm, 2006 Amtierender Dekan: Prof. Dr. Klaus-Michael Debatin 1. Berichterstatter Prof. Dr. Horst Hameister 2. Berichterstatter Prof. Dr. Werner Schempp Tag der Promotion: 05.05.2006 Erklärung Ich versichere hiermit, dass ich die vorliegende Arbeit selbstständig angefertigt und keine anderen als die angegebenen Quellen und Hilfsmittel benutzt sowie wörtlich oder inhaltlich übernommene Textpassagen als solche gekennzeichnet habe. Ulm, 27.01.2006 Violaine GOIDTS “Most scientific theories either deal with questions that only interest specialists or require a forbidding set of technical skills before you can understand them. The theory of evolution is scientifically unique in its combination of universal interests and accessibility.” ndMark Ridley, Evolution 2 Edition. Table of content 1. INTRODUCTION _______________________________________________ 10 1.1. Importance to do the human-chimpanzee comparison _________________ 10 1.2.