Identification of a chloride formate exchanger expressed on the brush border membrane of renal proximal tubule cells [Elektronische Ressource] / vorgelegt von Felix Knauf

Aus dem Institut für Physiologie der Universität Tübingen Geschäftsführender Direktor: Professor Dr. F. Lang Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells Inaugural-Dissertation zur Erlangung des Doktorgrades der Medizin der Medizinischen Fakultät der Eberhard-Karls-Universität zu Tübingen vorgelegt von Felix Knauf aus Freiburg 2005 Dekan: Professor Dr. C. D. Claussen 1. Berichterstatter: Professor Dr. F. Lang 2. Berichterstatter: Professor Dr. U. Quast Table of Content Table of content 1. Introduction 1.1. Physiology of the body fluids and the kidney 4 1.1.1. Composition of the body fluids 4 1.1.2. Structure and function of the kidney 5 1.2. Reabsorbtion of chloride in the proximal tubule 6 1.2.1. Fluid reabsorbtion in the proximal tubule 6-7 1.2.2. Identification of active chloride transport in the proximal tubule 8-12 1.2.3. Chloride - formate exchange: studies in vitro and in vivo 12 1.2.4. Pathways for chloride exit across the basolateral membrane of the proximal tubule 13 - 14 1.3. Identifying anion exchangers responsible for chloride reabsorbtion 15 1.3.1. The SLC26A family of mammalian anion transporters and their involvement in human genetic diseases 15-16 1.4.