Identification and functional characterization of extracellular signals affecting the expression of astroglial glutamate transporters [Elektronische Ressource] / Maciej Figiel

Abteilung Anatomie und ZellbiologieUniversität UlmLeiter: Prof. Dr. Dr. h.c. Ch. PilgrimIdentification and functional characterization ofextracellular signals affecting the expression ofastroglial glutamate transportersDissertationzu Erlangung des Doktorgrades der Humanbiologiean der Fakultät für Medizinder Universität UlmVorgelegt vonDiplom-Biotechnologe Maciej Figielaus Pozna , Polen2001Amtierender Dekan: Prof. Dr. med. Reinhard Marre1. Gutachter: Prof. Dr. Jürgen Engele2. Gutachter: Prof. Dr. med. Albert C. LudolphTag der Promotion: 19.10.2001Moim RodzicomFor my ParentsTABLE OF CONTENTS1. ABBREVIATIONS 32. INTRODUCTION 62.1. FUNCTION AND PHYSIOLOGY OF GLUTAMATE IN THE CNS....................................62.2. GLUTAMATE TRANSPORTERS AND THEIR PROPERTIES...........................................72.3. TRANSPORTERS IN ACUTE AND CHRONIC BRAIN DISEASES...................................92.4. REGULATION OF GLUTAMATE TRANSPORTERS........................................................102.5. PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDES (PACAPS).....112.6. PACAP FUNCTION IN THE CENTRAL NERVOUS SYSTEM.........................................132.7. FGF-2, EGF, TGF AND THEIR RECEPTORS IN THE CNS............................................132.8. AIMS OF THE WORK............................................................................................................143. MATERIALS AND METHODS 153.1. MATERIALS..................................