Identification and characterization of two novel primate-specific histone H3 variants H3.X and H3.Y [Elektronische Ressource] / Sonja M. Wiedemann

Dissertation zur Erlangung des Doktorgradesder Fakult¨at fu¨r Biologieder Ludwig-Maximilians-Universit¨at Mu¨nchenIdentification and Characterizationof Two Novel Primate-specific Histone H3 Variants,H3.X and H3.YSonja M. Wiedemannaus Mu¨nchenSeptember 2010Eingereicht am 30. September 2010Mu¨ndliche Pru¨fung am 20. Dezember 20101. Gutachter: Prof. Dr. Peter Becker2. Gutachter: Prof. Dr. Stefan Jentsch3. Gutachter: Prof. Dr. Heinrich Leonhardt4. Gutachter: Prof. Dr. Thomas Cremer5. SV: Dr. Sandra HakeEhrenwor¨ tliche VersicherungIch versichere hiermit ehrenw¨ortlich, dass die vorgelegte Dissertation von mir selbst¨andigund ohne unerlaubte Hilfe angefertigt wurde.Mu¨nchen,den.............................. ...............................................................(Sonja Wiedemann)AcknowledgementsFirst of all I want to thank Dr. Sandra Hake for giving me the opportunity to work on thisvery exciting project, for always finding time for discussions, even in busy times, for givinguseful scientific input, never running out of ideas when the project was stuck and for lettingme find my own way. Thank you for being a boss when I needed a boss and a friend when Ineeded a friend. You are doing a great job!I am grateful to Prof. Dr. Peter Becker for always having time for me, for his advice andconstant support and for providing not only a scientifically motivating environment but alsoa perfect lab atmosphere.