Identification and characterization of protein phosphatase 4 regulatory subunit 1 (PP4R1) as a suppressor of NF-_k63B [NF-kappaB] in T-lymphocytes and T-cell lymphomas [Elektronische Ressource] / presented by Markus Brechmann

Identification and Characterization of Protein Phosphatase 4 Regulatory Subunit 1 (PP4R1) as a Suppressor of NF- B in T Lymphocytes and T Cell Lymphomas DISSERTATION submitted to the Faculty of Biosciences of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor rerum naturalium presented by Dipl. Biochem. Markus Brechmann born in Bielefeld, Germany thOral-examination: September 10 , 2010 Identification and Characterization of Protein Phosphatase 4 Regulatory Subunit 1 (PP4R1) as a Suppressor of NF- B in T Lymphocytes and T Cell Lymphomas Referees: PD Dr. Philipp Beckhove German Cancer Research Center, Heidelberg Prof. Dr. Peter H. Krammer German CaThis thesis is based on research conducted in the Division of Immunogenetics at the German Cancer Research Center (DKFZ), under supervision of Prof. Dr. Peter H. Krammer and direct supervision of PD Dr. Rüdiger Arnold in the period from October 2006 to June 2010. „Chance favours the prepared mind.“ OUIS PASTEUR L Danksagung Denen, die mich in den zurückliegenden dreieinhalb Jahren während meiner Doktorarbeit unterstützt und begleitet haben, möchte ich meinen großen Dank aussprechen. Zunächst möchte ich mich bei Prof. Dr. Peter H. Krammer für seine Unterstützung und stete Diskussionsbereitschaft bedanken.