Identification and characterization of Leishmania major UDP-sugar pyrophosphorylase and determination of its impact on UDP-galactose metabolism [Elektronische Ressource] / Sebastian Damerow

Identification and Characterization of Leishmania major UDP-sugar Pyrophosphorylase and Determination of its Impact on UDP-galactose Metabolism Von der Naturwissenschaftlichen Fakultät der Gottfried Wilhelm Leibniz Universität Hannover zur Erlangung des Grades Doktor der Naturwissenschaften Dr. rer. nat genehmigte Dissertation von Dipl.-Biochem. Sebastian Damerow geboren am 4. März 1978 in Braunschweig 2010 Referentin: Prof. Dr. Rita Gerardy-Schahn Korreferentin: Prof. Dr. Françoise Routier Tag der Promotion: 11. März 2010 meinen Großeltern Herbert & Lucie „It is not the strongest species that survives, nor the most intelligent, but the one most responsive to change.” Charles Darwin, 1809-1882Table of Contents Table of Contents Zusammenfassung……... ………………………………………………………………………………..…………... 5 Summary………. …………………………………………………………………………………………….………… 7 CHAPTER 1 – General Introduction………. ................................................................................................... 8 1.1 Leishmania, Leishmaniasis and Leishmanicidals…………....…………………………………….… 8 1.2 Biology & Pathobiology………………………………………………………………………………….. 9 1.2.1 Hosts………………………………………………………………………………………….……...... 10 1.2.2 Life Cycle…………………………………………………………………………………...………... 10 1.2.3 Genome……………………………………………………………………………………………… 12 1.