Identification and characterization of IAPP derived inhibitors of cytotoxic self-assembly and amyloidogenesis of islet amyloid polypeptide (IAPP) and ß-amyloid [beta amyloid] peptide (Aß) [A beta] [Elektronische Ressource] / vorgelegt von Li-Mei Yan

Identification and characterization of IAPP-derived inhibitors of cytotoxic self-assembly and amyloidogenesis of islet amyloid polypeptide (IAPP) and β-amyloid peptide (A β) Von der Fakultät für Mathematik, Informatik und Naturwissenschaften der RWTH Aachen University zur Erlangung des akademischen Grades einer Doktorin der Naturwissenschaften genehmigte Dissertation vorgelegt von Master of Science Li-Mei Yan aus Jilin, VR China Berichter: Universitätsprofessor Dr. Aphrodite Kapurniotu (TU München) Universitätsprofessor Dr. Werner Baumgartner Tag der mündlichen Prüfung: 26. Aug. 2008 Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfügbar. Acknowledgement First of all I would like to thank Prof. Dr. Aphrodite Kapurniotu for giving me the opportunity to perform my Ph.D work under her supervision in the Laboratory of Bioorganic and Medicinal Chemistry at the Department of Biochemistry and Molecular Cell Biology in the Institute of Biochemistry of the RWTH Aachen. I thank her for her scientific advice, her numerous helpful discussions and her constant supervision of my scientific work. Her support and encouragement were especially valuable for my work. I also thank Prof. Kapurniotu for performing transmission electron microscopy. Special thanks also to Prof. Dr.