Identification and characterization of genes with specific expression in dendritic cells [Elektronische Ressource] / vorgelegt von Sven Heinz

Identification and Characterizationof Genes with Specific Expressionin Dendritic CellsDissertation zur Erlangung desDoktorgrades der Naturwissenschaften (Dr. rer. Nat.)der Naturwissenschaften Fakultät IV– Chemie und Pharmazie –der Universität Regensburgvorgelegt vonSven Heinzaus Kassel2002The work presented in this thesis was carried out in the Department of Hematology and Oncology atthe University Hospital Regensburg from October 1997 to December 2000 and Mai 2001 throughDecember 2001.Parts of this work have been published in:Heinz, S., Krause, S.W., Gabrielli, F., Wagner, H.M., Andreesen, R., Rehli, M. (2002). GenomicOrganization of the Human Gene HEP27: Alternative Promoter Usage in HepG2 Cells and Monocyte-Derived Dendritic Cells. Genomics 79, 608-615.Promotionsgesuch eingereicht am: 19. Juni 2002Die Arbeit wurde angeleitet von: PD Dr. med. S.W. KrausePrüfungsausschuß:Vorsitzender: Prof. Dr. Pfitzner1. Gutachter: Prof. Dr. Buschauer2. Gutachter: PD Dr. med. Krause3. Prüfer: Prof. Dr. SteinemTag der mündlichen Prüfung: 18. Juli 2002ToHeathermy wifeand mybest friend"Forty-two."Deep Thought, on the question of life,the universe and everythingin"Hitchhiker's Guide to the Galaxy"by Douglas AdamsTable of Contents1 Introduction ...................................................................................................... 11.1 The Immune System........................................................................................