Identification and analysis of patterns in DNA sequences, the genetic code and transcriptional gene regulation [Elektronische Ressource] / von Swetlana Nikolajewa

Identification and Analysis of Patternsin DNA sequences, the Genetic Codeand Transcriptional Gene RegulationDissertationzur Erlangung des akademischen Gradesdoctor rerum naturalium (Dr. rer. nat.)vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakult¨atder Friedrich-Schiller-Universit¨at Jenavon Magister der Mathematik Swetlana Nikolajewageboren am 19. November 1975 in Rostow-am-Don, RusslandDie vorliegende Arbeit wurde in der Arbeitsgruppe Theoretische Systembiolo-gie (TSB) des Leibniz-Instituts fur¨ Altersforschung Fritz-Lipmann-Institut e. V.(vormals IMB) unter der Leitung von Dr. Thomas Wilhelm angefertigt.Gutachter:1. Prof. Dr. Stefan Schuster2.3.Tag des Rigorosums:Tag der offen¨ tlichen Verteidigung:1AbstractThe present cumulative work consists of six articles linked by the topic ”Identifi-cation and Analysis of Patterns in DNA sequences, the Genetic Code and Tran-scriptional Gene Regulation”. We have applied a binary coding, to efficiently findpatterns within nucleotide sequences. In the first and second part of my workone single bit to encode all four nucleotides is used. The three possibilities ofa one - bit coding are: keto (G,U) - amino (A,C) bases, strong (G,C) - weak(A,U) bases, and purines (G,A) - pyrimidines (C,U). We found out that thebest pattern could be observed using the purine - pyrimidine coding.