Hyporesponsive synovial fluid T-cells in rheumatoid arthritis [Elektronische Ressource] / by Jan Thomas Barth

From the Clinical Research Unit for Rheumatologyand Department of Rheumatology and Clinical Immunologyof the University Hospital Freiburg i. BreisgauHyporesponsive Synovial Fluid T cells in Rheumatoid ArthritisInaugural-DissertationSubmitted for the Degree ofDoctor of Natural Sciencefrom the Faculty of Biologyof the Albert-Ludwigs-UniversityFreiburg i. BreisgaubyJan Thomas Barth2003Supervised by: PD Dr. Hermann EibelSecond censor: PD Dr. Ursula KlingmüllerSubmitted: 25. May 2003IndexIndex page1 Introduction1.1 Pathogenesis of rheumatoid arthritis (RA) 71.2 Cells involved in the pathogenesis RA 71.2.1 Fibroblast like synovial lining cells (synoviocytes) 71.2.2 Macrophages and monocytes 81.2.3 Neutrolphilic granulocytes 81.2.4 Dendritic cells (DC) 81.2.5 Osteoclasts & chondrocytes 101.2.6 B cells. 101.3 T cells 111.3.1 T cells in general. 111.3.2 T cell activation 111.3.3 TCR-mediated signal transduction. 121.3.4 Signaling of co-stimulatory receptor CD28 151.3.5 Regulation of T cell proliferation upon TCR and CD28 stimulation 171.3.6 Further T cell activation-modifying proteins 19+ + 1.3.7 Generation of CD4 T cells and CD8 CTL of effector and memory phenotype 19H+ + 1.3.8 Induction of hyporesponsiveness in CD4 T cells and CD8 CTL 20H1.3.8.1 T cell anergy 201.3.8.2 Regulatory suppressor T cells. 211.3.9 T 1 and T 2 cytokines 22H H1.3.9.1 IFN-γ and IL-2 231.3.9.2 IL-13 241.3.10 T cells in rheumatoid arthritis 24+ +1.