Hyperforin biosynthesis [Elektronische Ressource] : characterization and purification of a prenyltransferase from Hypericum calycinum cell cultures / von Zakia Boubakir

Hyperforin biosynthesis - Characterization and purification of a prenyltransferase from Hypericum calycinum cell cultures Von der Fakultät für Lebenswissenschaften der Technischen Universität Carolo-Wilhelmina zu Braunschweig zur Erlangung des Grades einer Doktorin der Naturwissenschaften (Dr. rer. nat) genehmigte D i s s e r t a t i o n von Zakia Boubakir aus Derna, Libyen 1. Referee: Prof. Dr. Ludger Beerhues 2. Referee: PD Dr. Dietrich Ober eingereicht am: 22.02.2006 mündliche Prüfung (Disputation) am: 25.04.2006 Publications Parts of this work have previously been published with permission of the Faculty of Chemistry and Pharmacy, represented by the mentor of this work: Publications Boubakir, Z., Beuerle,T., Liu, B., Beerhues, L. (2005). The first prenylation step in hyperforin biosynthesis. Phytochemistry 66: 51-57 Klingauf, P., Beuerle, T., Mellenthin, A., El-Moghazy, S.A.M., Boubakir, Z., Beerhues, L. (2005). Biosynthesis of the hyperforin skeleton in Hypericum calycium cell cultures. Phytochemistry 66 : 139-145 Beerhues, L., Abd El-Mawla, A., Beuerle, T., Boubakir, Z., Klingauf, P., Liu, B. (2005) Biosynthesis of active plant polyketide derivatives.