How does calcium oscillate? [Elektronische Ressource] : an interdisciplinary approach / von Alexander Skupin

How Does Calcium Oscillate?An Interdisciplinary ApproachDISSERTATIONzur Erlangung des akademischen Gradesdoctor rerum naturalium(Dr. rer. nat.)im Fach Biologieeingereicht an derMathematisch-Naturwissenschaftlichen Fakultät IHumboldt-Universität zu BerlinvonHerr Dipl.-Phys. Alexander Skupingeboren am 7.5.1976 in BraunschweigPräsident der Humboldt-Universität zu Berlin:Prof. Dr. Dr. h.c. Christoph MarkschiesDekan der Mathematisch-Naturwissenschaftlichen Fakultät I:Prof. Dr. rer. nat. Lutz-Helmut SchönGutachter:1. Prof. Dr. H. Herzel2. Priv.-Doz. Dr. M. Falcke3. Prof. Dr. C.W. Tayloreingereicht am: 15. Januar 2009Tag der mündlichen Prüfung: 3. Juni 2009Abstract2+Ca is the most important second messenger in living cells serving as a critical linkbetween a variety of extracellular stimuli and their intra- and intercellular responses.The external signals are translated most often into repeated increases of the cytoso-2+ 2+lic Ca concentration. Due to their importance and frequent appearance, Caoscillations have been extensively studied in experiments and most of the involvedphysiological elements are identified. Despite this knowledge, the link between thesemicroscopicts and the cellular dynamics is only vaguely understood.2+ 2+An important mechanism for generating cytosolic Ca transients is Ca releaseby channels from internal storage compartments, mainly from the endoplasmic retic-ulum and the sacroplasmic reticulum.