Host immune response in immunodeficient mice against infection with Cryptosporidium parvum [Elektronische Ressource] / Tesfaye Sisay Tessema

Host immune response in immunodeficient mice against infection with Cryptosporidium parvum Dissertation zur Erlangung des Grades “Doktor der Naturwissenschaften” am Fachbereich Biologie der Johannes Gutenberg-Universität Mainz Tesfaye Sisay Tessema geb. am 14.03.1974 in Dessie, Äthiopien Mainz, 2008 Tag der mündlichen Prüfung:10.12.2008 Table of contents I. ntroduction 1 1. Pathobiology of Cryptosporidium parvum 1 1.1. Cryptosporidium species 1 1.1.1. Brief history 1 1.1.2. Taxonomy 1.1.3. Life cycle 2 1.2. Human and animal cryptosporidiosis 2 1.2.1. Epidemiology 2 1.2.1.1. Target population of cryptosporidiosis 3 1.2.1.2. The transmission stage: Oocyst 4 1.2.1.3. Transmof infection 4 1.2.1.4. Zoonosis 4 1.2.2. Clinical features and pathogenesis 5 1.2.3. Diagnosis 6 1.2.4. Control and prevention of cryptosporidiosis 6 1.2.4.1. Chemotherapy 6 1.2.4.2. Passive immunotherapy 7 1.2.4.3. Immune reconstitution 1.2.4.4. Prevention 8 1.2.5. Animal models of C. parvum infection 8 1.3. Host immune response to C. parvum 9 1.3.1. Innate immunity 9 1.3.1.1. Interferon- γ (IFN- γ) and natural killer (NK) cell in innate immunity 9 1.3.1.2. The action of phagocytes against C. parvum 10 1.3.1.3.