HIV-1 resistance to fusion inhibitors [Elektronische Ressource] / presented by Raghavan Chinnadurai

University of Ulm Institute of Virology Director: Prof. Dr. Thomas Mertens HIV-1 Resistance to Fusion Inhibitors Dissertation To obtain the Doctoral Degree of Human Biology (Dr. biol. hum.) at the Faculty of Medicine, University of Ulm Presented by Raghavan Chinnadurai From Trichy, India 2006 Present Dean: Prof. Dr. Klaus-Michael Debatin 1. Reviewer: Prof. Dr. Frank Kirchhoff 2. Reviewer: Prof. Dr. Barbara Spellerberg Graduation Day: 15.02.2007 1. INDEX 1 1. Index ------------------------------------------------------------------------------------------- 1 2. List of Abbreviations---------------------------------------------------------------------- - 3 3. Introduction---------------------------------------------------------------- 6 3.1 HIV and AIDS-------------------------------------------------------------------------- 6 3.2 AIDS therapy and HIV-1 drug resistance------------------------------------------- 7 3.3 Multiple drug targets in HIV-1 entry------------------------------ 8 3.4 T-20, a first generation fusion inhibitor--------------------------------------------- 9 3.5 T-1249, a prototype second generation fusion inhibitor-------------------------- 11 3.6 Scientific aims-------------------------------------------------------------------------- 12 4. Materials-------------------------------------------------------------------------------------- 13 5.