Hippocampal correlation coding [Elektronische Ressource] : phase precession and temporal patterns in CA3 and CA1 / von Robert Schmidt

Hippocampal Correlation Coding:Phase Precession and Temporal Patterns in CA3 and CA1DISSERTATIONzur Erlangung des akademischen Gradesdoctor rerum naturalium(Dr. rer. nat.)im Fach Biologieeingereicht an derMathematisch-Naturwissenschaftlichen Fakultät IHumboldt-Universität zu BerlinvonHerr M.Sc. Robert Schmidtgeboren am 24.05.1979 in OsnabrückPräsident der Humboldt-Universität zu Berlin:Prof. Dr. Dr. h.c. Christoph MarkschiesDekan der Mathematisch-Naturwissenschaftlichen Fakultät I:Prof. Dr. Lutz-Helmut SchönGutachter:1. Prof. Dr. Richard Kempter2. Prof. Dr. Dietmar Schmitz3. Prof. Dr. David BilkeyTag der mündlichen Prüfung: 12. März 2010AbstractHippocampal correlation coding is a putative neural mechanism under-lying episodic memory. In this thesis, we look at two related phenomena:phase precession and reverse replay of behavioral sequences. Phase preces-sion refers to the decrease of the firing phase of a place cell with respect tothe local theta rhythm during the crossing of the place field. Reverse re-play refers to reactivation of previously experienced place field sequences inreverse order during awake resting periods.First, we study properties of phase precession in single trials. Usually,phase precession is studied only on the basis of data in which many placefield traversals are pooled together.