Hierarchically organized (hybrid) silica monoliths for the application as stationary phases in HPLC [Elektronische Ressource] / vorgelegt von Sarah Hartmann

Hierarchically Organized (Hybrid) Silica Monoliths for the Application as Stationary Phases in HPLC Dissertation zur Erlangung des akademischen Grades Doktor der Naturwissenschaften (Dr. rer. nat.) eingereicht an der Fakultät für Naturwissenschaften der Universität Ulm vorgelegt von Sarah Hartmann aus Starnberg 2009 Amtierender Dekan: Prof. Dr. Axel Groß Erstgutachterin: Prof. Dr. Nicola Hüsing Zweitgutachter: Prof. Dr. Boris Mizaikoff Tag der Promotion: 17. 03. 2010 Abstract Abstract This work deals with the sol-gel processing by employing diol-modified silanes as precursors towards hierarchically organized (hybrid) silica monoliths. With regard to their application as stationary phases in high performance liquid chromatography (HPLC), an important aspect is the hierarchical structuring with defined pore size domains in the mesoscopic and the macroscopic range. In order to avoid limitations of the diffusion pathways and the mass transfer within the monolithic column, a homogeneous co-continuous macroporous framework is desired, while an integrated mesoporous network allows for the separation of the chemical compounds.