Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin [Elektronische Ressource] / vorgelegt von Hua Cao

Aus der Medizinische Klinik und Poliklinik Abteilung Innere Medizin II der Albert-Ludwigs-Universität Freiburg i. Br. Heterogeneity of hepatitis C-virus in genotype 1 patients treated with the combination therapy of pegylated interferon and ribavirin INAUGURAL-DISSERTATION zur Erlangung des Medizinischen Doktorgrades Der Medizinischen Fakultät Der Albert-Ludwigs-Universität Freiburg i. Br. Vorgelegt 2004 von Hua Cao geboren in Wuhan, China Dekan: Prof. Dr. med. Josef Zentner 1. Gutachter: Prof. Dr. med. Jens W. F. Rasenack 2. Gutachter: Prof. Dr. med. Frank Hufert Jahr der Promotion: 2004 To my father Daode Cao, my mother Nailing Yun, and my sister Zhen Cao I 1. Introduction 01 1.1 Epidemiology of hepatitisC01 1.2 Hepatitis C Virus 01 1.2.1 Genome structure ofHCV02 1.2.1.1 The structural proteins 02 1.2.1.2 The non-structural proteins 03 1.2.2 Heterogeneity of HCV 04 1.2.2.1 Genotypes and subtypes 04 1.2.2.2 Quasispecies 04 1.3 Diagnosis of Hepatitis C 06 1.3.1 Laboratory Diagnosis 06 1.3.2 Clinical Diagnosis 06 1.3.3 Course of the disease 06 1.4 Therapy 07 1.4.1 Treatment of hepatitis C 07 1.4.1.1 Interferon 07 1.4.1.1.1 Classification and antiviral activity 07 1.4.1.1.2 Mechanisms of action 08 1.4.1.