Global cardiac phosphoproteome analysis in nitric oxide-induced heart [Elektronische Ressource] / submitted by Annamária Simon

Global Cardiac Phosphoproteome Analysis In Nitric Oxide-Induced Heart FailureInaugural-Dissertationto obtain the scientific degree Dr. rer. nat. of theDepartment of Mathematics and Natural Sciences of the Heinrich-Heine-University Düsseldorf submitted byAnnamária Simonfrom Keszthely (Hungary)Düsseldorf, June 2009From the Institute of Cardiovascular Physiologyof the Heinrich-Heine-University DüsseldorfPrinted with the authorization of the Department of Mathematics and Natural Sciences of theHeinrich-Heine-University DüsseldorfFirst Supervisor: Prof. MD Jürgen SchraderSecond Supervisor: Prof. Dr. Rainer WeinkaufDay of the oral examination: 16. July 2009 This work is dedicated to my familyACKNOWLEDGEMETNSACKNOWLEDGEMENTSFirst and foremost I would like to thank Prof. Dr. med. Jürgen Schrader for giving me the opportunity to work at his laboratory. I am deeply grateful for his excellent supervision at every stage of this work.Furthermore, I would like to thank Prof. Dr. Rainer Weinkauf for the fast preparation of the expert opinion. I would also like to thank the Graduate College 1089 “Protein interactions and modifications in the heart“ for the interesting courses and for the financial support. Additionally I would like to thank Prof. Dr. Albert Sickmann for giving me some practical tips and tricks in proteomics.