Genomewide Characterization of Host-Pathogen Interactions by Transcriptomic Approaches [Elektronische Ressource] / Maren Depke

G E N O M E W I D E C H A R A C T E R I Z A T I O N O F H O S T - P A T H O G E N I N T E R A C T I O N S B Y T R A N S C R I P T O M I C A P P R O A C H E S I N A U G U R A L D I S S E R T A T I O N ZUR ERLANGUNG DES AKADEMISCHEN GRADES DOCTOR RERUM NATURALIUM (DR. RER. NAT.) AN DER MATHEMATISCH-NATURWISSENSCHAFTLICHEN FAKULTÄT DER ERNST-MORITZ-ARNDT-UNIVERSITÄT GREIFSWALD VORGELEGT VON MAREN DEPKE GEBOREN AM 11. 01. 1978 IN HAMBURG GREIFSWALD, DEN 24. 09. 2010 Dekan: Prof. Dr. rer. nat. Klaus Fesser 1. Gutachter : Prof. Dr. rer. nat. Uwe Völker 2. Gutachter: Prof. Dr. rer. nat. Christiane Wolz Tag der Promotion: 22. 12. 2010 Maren Depke C O N T E N T S GENOMEWIDE CHARACTERIZATION OF HOST-PATHOGEN INTERACTIONS BY TRANSCRIPTOMIC APPROACHES 1 CONTENTS 3 ZUSAMMENFASSUNG DER DISSERTATION 5 SUMMARY OF DISSERTATION 9 INTRODUCTION 13 INFECTIOUS DISEASES AND IMMUNE SYSTEM 13 Aspects of Innate Immunity 13 Aspects of Adaptive Immunity 16 Modulation of Immune Reactions 18 STAPHYLOCOCCUS AUREUS 20 General Features of S. aureus 20 S. aureus, a Commensal and Opportunistic Pathogen 21 S. aureus Virulence Factors 22 Mechanisms of S. aureus Adaptation to its Environment 28 Increasing Importance and Danger of S.