Genetic studies on functional redundancy between profilin1 and profilin2 in mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior [Elektronische Ressource] / [presented by Agnieszka Sadowska]

Dissertationsubmitted to the combined Faculties for the Natural Sciences and forMathematics of the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural SciencesPresented byAgnieszka SadowskaDiploma: Master of Biotechnology, University of GdanskBorn in Gdansk, PolandOral examination:1Genetic studies on functional redundancy betweenprofilin1 and profilin2 in mice and the role of the profilinligand Mena in neuronal cell function and mouse behaviorReferees: Prof. Dr Jochen WittbrodtProf. Dr Klaus Unsicker2AcknowledgementsI want to thank my supervisor Walter Witke for giving me the possibility to carry on thisproject in his group.I would like to express my gratitude Dr Anne Cecile Trillat for teaching me themethodology used for neuronal cultures and showing an incredible passion forneuroscience. Thank you Cecile for your support to the whole idea as well as foryour critical eye looking at my results and their interpretation, but above all foryour presence.I would like to thank the members of The Phenotyping Core Facility, EMBLMonterotondo Karin Gale and Janice Carter help in Analysis of theMena KO mice.I would like to thank Pietro Pilo Boyl for involvement in teaching me what is theperfection and for critical comments and discussions on this thesis. Grazie Pietro.I would like to than Jakky Kelly-Barrett for the injection of my ES cells andgeneration two of my knock-in mice.