Genetic modification of oncolytic adenoviruses for anti-cancer-therapy [Elektronische Ressource] / presented by Christina Quirin

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences Presented by Diplom Biologin Christina Quirin born in: Munich Oral-examination: Genetic Modification of Oncolytic Adenoviruses for Anti-Cancer-Therapy Referees: PD Dr. Suat Özbek PD Dr. Dirk NettelbeckTable of Contents Zusammenfassung ...................................................................1 1.  Summary ..............................................................................2 2.  Introduction .........................................................................3 2.1.  Cancer and cancer therapies ............................................................... 3 2.2.  Gene therapy for cancer treatment ...................................................... 4 2.3.  Virotherapy for cancer treatment ......................................................... 8 2.4.  Adenovirus and their use as gene therapy vector or oncolytic virus ................................................................................................................ 9 2.4.1.  Adenoviruses: Virion Structure, Cell Entry and Genome Organization ......... 10 2.4.1.1.  Serotypes and Virus Structure ............................................................