Genetic and phenotypic characterisation of the Cftr_1hnT_1hng_1hnH_1hn(_1hnn_1hne_1hno_1hni_1hnm_1hn)_1hnH_1hng_1hnu cystic fibrosis mouse models [Elektronische Ressource] = Mausmodelle für die zystische Fibrose: geno- und phänotypische Charakterisierung der Cftr_1hnT_1hng_1hnH_1hn(_1hnn_1hne_1hno_1hni_1hnm_1hn)_1hnH_1hng_1hnu-Mäusestämme / von Nikoletta Charizopoulou

TgH(neoim)HguGenetic and phenotypic characterisation of the Cftrcystic fibrosis mouse modelsMausmodelle für die zystische Fibrose: Geno-und phänotypischeTgH(neoim)HguCharakterisierung der Cftr MäusestämmeVon Fachbereich Chemieder Universität Hannoverzur Erlangung des GradesDoktorin der NaturwissenschaftenDr.rer.natgenehmigte DissertationvonDr.rer.nat. Nikoletta Charizopoulougeboren am 14.03.1977 in Alexandroupolis, GriechenlandReferent: Prof. Dr. Burkhard TümmlerKorreferent: Prof. Dr. Hans. J. HedrichTag der Promotion: 30.01.042To my parents.( In Greek) Στους γο ν ε ί ς µου.„Whoever you are, or whateverit is that you do, when you really wantsomething it is because that desire originated in the soul of the universe,and so when you want something, all the universe conspires in helpingyou to achieve it.”Paulo Coelho“The Alchemist”3AcknowledgementsThe work for this thesis started in September 2000 and was accomplished in July 2003 at thelaboratory of the Klinischen Forschergruppe under the supervision of Prof. B. Tümmler andProf. H.J. Hedrich.My special thanks go to Prof. B. Tümmler and Prof. H.J. Hedrich for trusting me with thisproject and for giving me the opportunity with their unlimited support and guidance toimprove my academic qualifications.I would also like to thank Dr. J. Dorin (MRC, Edinburgh) for providing us with the mousemodel.