Generation of transgenic mice with regulated expression of manganese superoxide dismutase (MnSOD) [Elektronische Ressource] / by Tomasz Loch

Generation of transgenic mice with regulated expression of manganese superoxide dismutase (MnSOD) Doctoral Thesis submitted to Mathematisch-Naturwissenschaftlich-Technische Fakultät Martin-Luther-Universität Halle-Wittenberg by Tomasz Loch born 22.11.1971 in Siemianowice Śl ąskie, Poland Reviewers: 1. Prof. Thomas Braun 2. Prof. Thomas Noll Datum der Verteidigung: 15.09.2006, Halle (Saale) urn:nbn:de:gbv:3-000010674[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000010674]Contents 1 INTRODUCTION..................................................................................................1 1.1 Free radicals, oxidative stress and antioxidant enzymes ................................................ 1 1.1.1 Free radicals............................................................................................................. 1 1.1.2 Free radicals in physiology...................................................................................... 2 1.1.3 Oxidative stress........................................................................................................ 3 1.1.4 Antioxidant enzymes (AOEs).................................................................................. 3 1.1.4.1 Copper zinc superoxide dismutase (CuZnSOD) .............................................. 4 1.1.4.2 Extracellular superoxide dismutase (ECSOD) ................................................. 5 1.1.4.