Generation and characterization of SIVagmSab infectious molecular clone and its HIV-1 like derivative [Elektronische Ressource] / Clement Wesley Gnanadurai

University of Ulm Institute of Molecular Virology Director: Prof. Dr. Frank Kirchhoff Generation and characterization of SIVagmSab infectious molecular clone and its “HIV-1 like” derivative Dissertation to obtain the Doctoral Degree of Human Biology (Dr. biol. hum.) at the Faculty of Medicine, University of Ulm. Presented by Clement Wesley Gnanadurai Ulm 2011 Present Dean: Prof. Thomas Wirth 1. Reviewer: Prof. Frank Kirchhoff 2. Reviewer: Prof. Bernhard Eikmanns Graduation Day: 18.07. 2011 INDEX i Index List of Abbreviations.....................................................................................................................IV 1. Introduction.................................................................................................................................1 1.1 Discovery, origin and genomic organization of HIV..........................................................1 1.2 Nef: a multifunctional viral persistence factor.....................................................................3 1.3 Nef: natural and experimental SIV infection and clinical outcome……………...………..4 1.4 SIV infection of African green monkeys as a model for AIDS pathogenesis.…...…...…..6 1.5 Scientific aims…………………………………………………..……………...............….8 2. Materials and Methods………………………………………………….….…..……..……...…8 2.1 Materials……………………………………………………………………..