Functional genome analysis of the plant-growth promoting bacterium Bacillus amyloliquefaciens strain FZB42; characterizing its production and regulation of nonribosomal peptide synthetases [Elektronische Ressource] / Alexandra Koumoutsi

Humboldt-Universität zu Berlin D i s s e r t a t i o n Functional genome analysis of the plant-growth promoting bacterium Bacillus amyloliquefaciens strain FZB42; characterizing its production and regulation of nonribosomal peptide synthetases zur Erlangung des akademischen Grades d o c t o r r e r u m n a t u r a l i u m Mathematisch-Naturwissenschaftlichen Fakultät I Dipl. Chem. Alexandra Koumoutsi Dekan: Prof. Dr. Christian Limberg Gutachter: 1. Professor Dr. Rainer Borriss 2. PD Dr. habil. Joachim Vater eingereicht: 11.10.2006 Datum der Promotion: 04.12.2006 List of contents Introduction............................................................................................................................. 17 Bacillus amyloliquefaciens strain FZB42...................................................................................... 17 Genome sequencing ........................................................................................................................ 17 Antibiotic production from Bacilli ................................................................................................ 18 Ribosomally synthesized peptide antibiotics............................................................................................... 20 Synthesis.................................................................................................................................................