Functional characterization of voltage-gated sodium channels associated with human idiopathic epilepsies [Elektronische Ressource] / vorgelegt von Yunxiang Liao

Universität Ulm Abteilungen Angewandte Physiologie und Neurologie Abteilungsleiter: Prof. Dr. F. Lehmann-Horn Prof. Dr. A. C. Ludolph Functional Characterization of Voltage-gated Sodium Channels associated with human Idiopathic Epilepsies Dissertation Zur Erlangung des Doktorgrades der Humanbiologie der Medizinischen Fakultät der Universität Ulm Vorgelegt von: Yunxiang Liao aus Guilin, V.R.China Ulm, 2009 Amtierender Dekan: Prof. Dr. Klaus-Michael Debatin 1. Berichterstatter: Prof. Dr. Holger Lerche 2. Berichterstatter: Prof. Dr. Harald Bode Tag der Promotion: 26. Juni 2009 ii TABLE OF CONTENTS 1. INTRODUCTION ....................................................................................................... 1 1.1. VOLTAGE-GATED SODIUM CHANNELS.......................................................................... 1 1.1.1. Diversity of voltage-gated sodium channel α subunits........................................ 3 1.1.2. Function of voltage-gated sodium channels in the brain .................................... 4 1.1.3. The auxiliary β subunits ...................................................................................... 6 1.2. IDIOPATHIC EPILEPSY................................................................................................... 8 1.2.1. Generalized epilepsy with febrile seizures plus................................................... 8 1.2.2.