Functional characterization of KCNJ2 mutations associated with Andersen-Tawil syndrome and atrial tachycardia [Elektronische Ressource] / vorgelegt von Georgeta Teodorescu

Universität Ulm Institute für Angewandte Physiologie Prof. Dr. Dr. h. c. Frank Lehmann-Horn Functional characterization of KCNJ2 mutations associated with Andersen-Tawil syndrome and atrial tachycardia Dissertation zur Erlangung des Doktorgrades der Humanbiologie (Dr. biol. hum.) der Medizinischen Fakultät der Universität Ulm vorgelegt von Georgeta Teodorescu Bukarest, Rumänien 2007 Amtierender Dekan: Prof. Dr. Klaus-Michael Debatin 1. Berichterstatter: Prof. Dr. Stephan Grissmer 2. Berichterstatter: PD Dr. Karl Föhr Tag der Promotion: 24.07.2007 TABLE OF CONTENT 1 INTRODUCTION ............................................................................................................ 1 1.1 General description of potassium channels .................................................................... 1 1.2 Inward-rectifier potassium channels (Kir)...................................................................... 2 1.2.1 Molecular assembly of Kir channels ............................................................................ 2 1.2.2 Molecular structure of Kir channels ............................................................................. 4 1.2.3 Physiological functions and expression of Kir channels.............................................. 5 1.2.4 Mechanism and determinants of inward-rectification...................