Functional characterization of early growth response transcription factor 2 (EGR-2) [Elektronische Ressource] / von Katarina Ludajic

Functional characterization of Early GrowthResponse Transcription Factor 2 (EGR-2)DISSERTATIONzur Erlangung des akademischen GradesDoctor rerum naturalium (Dr. rer. nat.)vorgelegt dem Rat derBiologisch-Pharmazeutischen Fakultät derFriedrich-Schiller-Universität JenavonKatarina Ludajicgeboren am 7. April 1975in BelgradGutachter:1. Prof. Dr. Peter Zipfel………………………..................................……….2. Prof. Dr. Frank Große…………………..................................……………….3. PD Dr. Hermann Eibel……………..................................…………………….Tag des Rigorosums: 22.06.2005………………………………….Tag der öffentlichen Verteidigung: 18.07.2005.……………………………….Table of ContentsTable of ContentsTable of contents IAbbreviations VZusammenfassung VIISummary IX1 Introduction .................................................................................................................... 11.1 The Immune System................................................................................................... 11.2 Inflammation................. 21.2.1 Mediators of inflammation.................................................................................. 41.2.2 The role of transcription factors in inflammation............. 61.3 The ‘Immediate early’ genes...................... 81.4 The ‘Early growth response’ protein family ............................................................. 81.4.1 The structure of EGR proteins...............................