Functional characterization of candidate tumor suppressor genes localized in the critical chromosomal region 13q14 [Elektronische Ressource] / presented by Leticia Serra Barrionuevo

Functional characterization of candidate tumor suppressor genes localized in the critical chromosomal region 13q14 INAUGURAL-DISSERTATION for the degree of Doctor rerum naturalium (Dr. rer. nat.) Faculty of Natural Sciences Universty of Ulm 2008 Presented by Leticia Serra Barrionuevo born in Málaga, Spain. Dean of the Faculty of Natural Sciences University of Ulm Prof. Dr. Klaus-Dieter Spindler First Reviewer: Prof. Dr. Thomas Wirth Head of the division of Physiological Chemistry from the Faculty of Natural Sciences University of Ulm Second Reviewer: Date of the conferral of the doctorate: To my family, for giving me more than words could possibly describe “La realidad, pues, se ofrece en perspectivas individuales.” “Reality, thus, presents itself in each individual perspective.” José Ortega y Gasset “Damit das Mögliche entsteht, muss immer wieder das Unmögliche versucht werden.“ „In order for what is possible to emerge, the impossible must be tried over and over again.” Hermann Hesse Index Index: Abbreviations……………………………………..........i 1. Introduction...........................................................1 1.1. Molecular basis of cancer.............................................................................. 1 1.2. Chronic Lymphocytic Leukemia .................