Functional characterization of BCL11B-a human transcription factor and UBR1-a human protein ubquitin ligase aided by proteomic analysis [Elektronische Ressource] / vorgelegt von Narasimha Kumar Karanam

Functional characterization of BCL11B-a human transcription factor and UBR1-a human protein ubquitin ligase aided by proteomic analysis I n a u g u r a l d i s s e r t a t i o n zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) an der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald vorgelegt von Narasimha Kumar Karanam geboren am 16.07.1979 Nandyal, India Dekan: Prof. Dr. rer. nat. Klaus Fesser 1. Gutachter: Prof. Dr. rer. nat. Uwe Volker 2. Gutachter: Prof. Dr. rer. nat. Walter Halangk Tag der Promotion: 22nd November 2010 … … ..dedicated to my dear parents and wife Dissertation Content Content Content ............................................................................................................................................. 1 1. Abbreviations .......................... 5 2. Summary . 7 2.1. Characterization of the role of BCL11b in Human T cell lymphomas......................... 7 2.2. Elucidation of the mechanism of pathophysiology of Johanson Blizzard Syndrome using UBR1 knockout mice and JBS patients‟ lymphoblasts cell lines .....................