Functional characterization of a putative Plasmodium falciparum calcium-hydrogen antiporter pfcha [Elektronische Ressource] / vorgelegt von Wendyam Armand Guiguemde

INAUGURAL-DISSERTATION zur Erlangung der Doktorwürde der Naturwissenschaftlich-Mathematischen Gesamtfakultät der Ruprecht-Karls-Universität Heidelberg vorgelegt von Wendyam Armand GUIGUEMDE aus Bordeaux (FRANKREICH) Tag der mündlichen Prüfung: 25. November 2005 Thema Functional characterization of a putative Plasmodium falciparum calcium/hydrogen antiporter pfcha Gutachter: Prof. Dr. Michael Lanzer Prof. Dr. Heiner Schirmer Die vorliegende Arbeit wurde am Hygiene-Institut, Abteilung Parasitologie, Heidelberg in der Zeit von März 2001 bis September 2005 unter der Leitung von Prof. Dr. Michael Lanzer durchgeführt. ACKNOWLEDGEMENTS I am very thankful to Prof. Dr. Lanzer for having given me the chance to work in his laboratory, for his patience, his constant encouragements and support. I am also thankful to Prof. Dr. Schirmer for his generosity, his kindness, his approachability and modesty despite the vast knowledge he has. Thank you Prof. Schirmer. Special thanks to Dr. Cecilia Sanchez who had the hard job to teach a neophyte the molecular biology techniques and to Dr. Susanne Nessler for her help with the oocytes. A special mention to Elisabeth for her willingness to help in the lab. A “polite” thank to Dr. Jeremy Mclean for his help to review the manuscript of my thesis and also for the nice scientific discussions.