Functional characterization of a glutamate transporter from Escherichia coli [Elektronische Ressource] / Ivanna Shcherbyna

Functional characterization of a glutamate transporter from Escherichia coli Ivanna Shcherbyna Functional characterization of a glutamate transporter from Escherichia coli Von der Naturwissenschaftlichen Fakultät der Gottfried Wilhelm Leibniz Universität Hannover zur Erlangung des Grades Doktorin der Naturwissenschaften -Dr. rer. nat.- genehmigte Dissertation von Ivanna Shcherbyna, Magistr Diplom, geboren am 20. Januar 1976, in Kiew, Ukraine 2009 Referent: Prof. Dr. Christoph Fahlke Korreferent: Prof. Dr. Anaclet Ngezahayo Tag der Promotion: 12-August-2009 Dedicated to my dear sister Oleksandra Contents Contents 1. Introduction............................................................................................................ 1 1.1 Neurotransmitter transporters................................................................................. 2 1.2 L-glutamate as a neurotransmitter.......................................................................... 3 1.2.1 Role of glutamate uptake in disease.............................................................. 4 1.3 Glutamate transporters............................................................................................ 5 1.3.