Functional characterisation of arteries and urinary bladder from mice with genetic ablation of the large conductance Ca_1hn2_1hn+ and voltage activated K_1hn+ (BK) channel [Elektronische Ressource] / vorgelegt von Iancu Valeriu Bucurenciu

Aus dem Pharmazeutischen Institut der Universität Tübingen Abteilung Pharmakologie und Toxikologie Leiter: Prof. Dr. Dr. P. Ruth Functional characterisation of arteries and urinary bladder from mice with genetic ablation of the large 2+ +conductance Ca and voltage activated K (BK) channel Inaugural-Dissertation zur Erlangung des Doktorgrades der Medizin der Medizinischen Fakultät der Eberhard Karls Universität zu Tübingen vorgelegt von Iancu Valeriu Bucurenciu 2005 Dekan: Professor Dr. C.D. Claussen 1. Berichterstatter Professor Dr. P. Krippeit-Drews 2. Professor Dr. U. Quast Für Lavinia in Liebe Table of content 1. Introduction 1 2+ +1.1. Large conductance Ca and voltage activated K channels 1 + 2+ + 1.1.1. Ion channels, K channels and Ca -activated K channels 1 1.1.2. BK channels 2 Topology of BK channel 3 Gating of BK channel 4 1.2. The role of BK channels in smooth muscles 5 1.2.1. Smooth muscle contraction 5 1.2.2. Smooth muscle relaxation; the role of cAMP and cGMP 7 The cAMP and cGMP pathways in arteries and urinary bladder 8 1.2.3. Regulation of BK channels in smooth muscles 9 1.3. Aim of this study 12 2. Methods 14 2+2.1.