Function of the {α1B1 [alpha1B1] subunit of Na_1hn+, K_1hn+ ATPase during zebrafish heart development [Elektronische Ressource] / von Elena Cibrián-Uhalte

+ +Function of the α1B1 subunit of Na ,K ATPase during zebrafish heart development DISSERTATION zur Erlangung des Akademischen Grades doctor rerum naturalium (Dr. rer. nat.) im Fach Biologie eingereicht an der Mathematisch-Naturwissenschaftlichen Fakultät I der Humboldt-Universität zu Berlin von Elena Cibrián-Uhalte Geboren am 12.02.1977 in Santander (Spanien) Präsident der Humboldt-Universität zu Berlin Prof. Dr. Christoph Markschies Dekan der Mathematisch-Naturwissenschaftlichen Fakultät I Prof. Dr.Christian Limberg Gutachter: 1. Prof. Dr. Harald Saumweber 2. Prof. Dr. Achim Leutz 3. Prof. Dr. Thomas Willnow Tag der mündlichen Prüfung: 21. July 2008 Abstract Abstract + +Na ,K ATPase is an essential ion pump involved in regulating ionic concentrations within epithelial cells. The zebrafish heart and mind ( had) + +mutation which disrupts the α1B1 subunit of Na ,K ATPase causes heart tube elongation defects and other developmental abnormalities that are reminiscent of several epithelial cell polarity mutants including nagie oko (nok) and heart and soul (has). In this work, I investigated the function and regulatory + +mechanisms of Had/Na ,K ATPase during zebrafish cardiac morphogenesis, as well as its´ possible interactions with Has/Prkci and Nok/Mpp5.