Fibrin for tissue engineering of cartilage [Elektronische Ressource] / presented by Daniela Eyrich

Fibrin for Tissue Engineering of Cartilage Dissertation to obtain the Degree of Doctor of Natural Sciences (Dr. rer. nat.) from the Faculty of Chemistry and Pharmacy University of Regensburg Presented by Daniela Eyrich from Bad Kissingen April 2006 This work was carried out from February 2002 until December 2005 at the Department of Pharmaceutical Technology of the University of Regensburg. The thesis was prepared under supervision of Prof. Dr. Achim Göpferich. Submission of the PhD. application : 24.04.2006 Date of examination : 18.05.2006 Examination board : Chairman: Prof. Dr. Elz 1. Expert: Prof. Dr. Göpferich 2. Expert: PD Dr. Staudenmaier 3. Examiner: Prof. Dr. Heilmann ‘If we consult the standard surgical writers from Hippocrates down to present age, we shall find that an ulcerated cartilage is found to be a very troublesome disease [...] and that when destroyed, it is never recovered.’ W. Hunter Roy Soc London, Phil Trans 9:267-271 (1743) Table of Contents Chapter 1 Goals of the Thesis ..................................................................7 Chapter 2 Introduction - Fibrin in Tissue Engineering ...............................11 Chapter 3 Factors Influencing Chondrocyte Behavior and Development of Cartilaginous Tissue in Three-Dimensional Fibrin Gel.............