Exzitotoxizität im ZNS bei Mausmutanten mit veränderten Glutamatrezeptoren [Elektronische Ressource] / presented by Irinel Andreea Coserea

DISSERTATIONsubmitted to theCombined Faculties for the Natural Sciences and for Mathematicsof the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural Sciences presented byBiologist Irinel Andreea Cosereaborn in Bucharest, Romaniaoral examination: 3.03.2005Exzitotoxizität im ZNS beiMausmutanten mitveränderten GlutamatrezeptorenGutachter: Prof. Dr. Hannah MonyerProf. Dr. Peter Seeburg1.INTRODUCTION............................................................................................................................................................... 31.1 Preface................................... 31.2 Signal transmission in the central nervous system. 31.3 Excitatory and inhibitory synaptic transmission .................................................................... 51.4 Ionotropic glutamate receptors .............................................................. 61.4.1 Classification of ionotropic glutamate receptors................................ 61.4.2 Sructure of ionotropic glutamate receptors......... 61.4.3 The Q/R/N site of ionotropic glutamate receptors............................................................................................... 71.4.4 Subunit stoichiometry .......................................................................... 81.5 The NMDA receptor............................................................................... 81.5.