Expression profiling by DNA microarrays [Elektronische Ressource] : development of amplification methods for the analysis of minimal tumor samples / presented by Jörg Schlingemann

Expression Profiling by DNA Microarrays: Development of Amplification Methods for the Analysis of Minimal Tumor Samples DISSERTATION submitted to the Combined Faculties for the Natural Sciences and Mathematics of the Ruperto-Carola-University of Heidelberg for the degree of Doctor of Natural Sciences presented by DIPL.-BIOL. JÖRG SCHLINGEMANN born in Hagen in 1975 2005 DISSERTATION submitted to the Combined Faculties for the Natural Sciences and Mathematics of the Ruperto-Carola-University of Heidelberg for the degree of Doctor of Natural Sciences presented by DIPL.-BIOL. JÖRG SCHLINGEMANN born in Hagen in 1975 thoral examination: September 30 , 2005 Expression Profiling by DNA Microarrays: Development of Amplification Methods for the Analysis of Minimal Tumor Samples Referees: PD Dr. Karsten Rippe Prof. Dr. Peter Lichter T ABLE OF CONTENTS V I. TABLE OF CONTENTS P AGE I. TABLE OF CONTENTS V II. PUBLICATIONS, PEER-REVIEWED IX III. P, NON PEER-REVIEWED IV. POSTERS X V. ACKNOWLEDGEMENTS XI VI. ABBREVIATIONS XII VII. ABSTRACT XV VIII. ZUSAMMENFASSUNG XVI 1 INTRODUCTION 1 1.1 Cancer Statistics 2 1.2 The Human Genome 5 1.3 Genetic Aberrations of Cancer Cells 7 1.3.1 Oncogenes 7 1.3.2 Tumor Suppressor Genes 9 ‘Mutator Genes’ 10 1.4 Multistage Carcinogenesis 11 1.