Expression kinetics of viral oncogenes, miRNAs and their targets during papilloma development in human papillomavirus 8 transgenic mice [Elektronische Ressource] / vorgelegt von Martin Hufbauer

Expression kinetics of viral oncogenes, miRNAs and their targets during papilloma development in human papillomavirus 8 transgenic mice Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Universität zu Köln vorgelegt von Martin Hufbauer aus Freiburg copy team cologne, Köln 2010 Berichterstatter: Prof. Dr. Dr. h.c. Herbert Pfister Prof. Dr. Manolis Pasparakis Vorsitzender: Prof. Dr. Matthias Hammerschmidt Beisitzerin: Dr. Gertrud Steger Tag der Disputation: 19.04.2010 Table of content I 1 Introduction ..................................................................................... 1 1.1 Papillomavirus structure ........................................................................... 1 1.2 HPV taxonomy ............................................................................................ 2 1.3 HPV life cycle .............................................................................................. 3 1.4 Functions of the viral proteins .................................................................. 4 1.4.1 E2 protein .......................................................................................................... 4 1.4.2 E6 protein .......................................................................................................... 5 1.4.3 E7 protein ..................................