Expression and function of thrombin receptors (PAR1, PAR3 and PAR4) in human umbilical vein endothelial cells [Elektronische Ressource] : thrombin-mediated CX3CL1 expression / submitted by Milan Popović

University of Ulm Department of Pharmacology of Natural Products and Clinical Pharmacology Head: Prof. Thomas Simmet, MD. Ph.D Expression and Function of Thrombin Receptors (PAR1, PAR3 and PAR4) in Human Umbilical Vein Endothelial Cells: Thrombin-mediated CX3CL1 Expression Thesis Presented to the Faculty of Medicine, University of Ulm, to obtain the degree of a Doctor of Human Biology Submitted by Milan Popovi from Kragujevac, Serbia December 2006 ć Amtierender Dekan: Prof. Klaus Debatin 1. Berichterstatter: Prof. Thomas Simmet 2. Berichterstatter: Prof. Nikolaus Marx thTag der Promotion: 8 December 2006 In memoriam Mojoj dragoj babi, Danici Table Of Contents Table of Contents TABLE OF CONTENTS I ABBREVATIONS III 1 INTRODUCTION 1 1.1 P RINCIPLES OF THE VASCULAR TRANSMIGRATION OF LEUKOCYTES 1 1.1.1 E NDOTHELIUM AS A SENSOR FOR INFLAMMATION 1 1.1.2 I NTERACTION BETWEEN ENDOTHELIAL CELLS AND LEUKOCYTES 2 1.2 H UMAN CYTOMEGALOVIRUS 11 1.2.